Effect of Rimantadine on Cytotoxic T Lymphocyte Responses and Immunity to Reinfection in Mice Infected with Influenza A Virus
Identifieur interne : 002092 ( Main/Exploration ); précédent : 002091; suivant : 002093Effect of Rimantadine on Cytotoxic T Lymphocyte Responses and Immunity to Reinfection in Mice Infected with Influenza A Virus
Auteurs : John E. Herrmann [États-Unis] ; Kim West ; Matthew Bruns ; Francis A. EnnisSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1990.
Abstract
Administration of rimantadine to mice via drinking water, following a prophylactic dose, reduced lung virus titers by >3 log10 plague-forming units (pfu)/ml but caused only marginal reductions in lung virus titers when therapy wasstarted 8 h after exposure to virus. Mice given rimantadine prophylactically plus therapeutically were resistant to rechallenge with virus at a dose equivalent to that used for the primary infection (SO pfu/mouse) but not to a high dose (1 × 105 pfu/mouse). VIrUS-neutralizing-antibody titers were reduced only by rimantadine treatment, which included prophylaxis, whereas the cytotoxic T lymphocyte (CTL) response was depressed by treatment givenwith or without prophylaxis.Miceinfected with rimantadine-resistant virus had no decrease in CTL or antibody responses when treated with rimantadine. Therefore, the depression in CTL and antibody responses associated with rimantadine treatment appears to bedue to a decrease in the amount of viral antigen available or interference with viral antigen processing and not to nonspecific immunosuppressive effects.
Url:
DOI: 10.1093/infdis/161.2.180
Affiliations:
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Herrmann</name><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Reprints and correspondence: Dr. John E. Herrmann, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="West, Kim" sort="West, Kim" uniqKey="West K" first="Kim" last="West">Kim West</name><affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation></author><author><name sortKey="Bruns, Matthew" sort="Bruns, Matthew" uniqKey="Bruns M" first="Matthew" last="Bruns">Matthew Bruns</name><affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation></author><author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name><affiliation><wicri:noCountry code="subField">Worcester</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1990-02">1990</date><biblScope unit="vol">161</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="180">180</biblScope><biblScope unit="page" to="184">184</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Administration of rimantadine to mice via drinking water, following a prophylactic dose, reduced lung virus titers by >3 log10 plague-forming units (pfu)/ml but caused only marginal reductions in lung virus titers when therapy wasstarted 8 h after exposure to virus. Mice given rimantadine prophylactically plus therapeutically were resistant to rechallenge with virus at a dose equivalent to that used for the primary infection (SO pfu/mouse) but not to a high dose (1 × 105 pfu/mouse). VIrUS-neutralizing-antibody titers were reduced only by rimantadine treatment, which included prophylaxis, whereas the cytotoxic T lymphocyte (CTL) response was depressed by treatment givenwith or without prophylaxis.Miceinfected with rimantadine-resistant virus had no decrease in CTL or antibody responses when treated with rimantadine. Therefore, the depression in CTL and antibody responses associated with rimantadine treatment appears to bedue to a decrease in the amount of viral antigen available or interference with viral antigen processing and not to nonspecific immunosuppressive effects.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Bruns, Matthew" sort="Bruns, Matthew" uniqKey="Bruns M" first="Matthew" last="Bruns">Matthew Bruns</name><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name><name sortKey="West, Kim" sort="West, Kim" uniqKey="West K" first="Kim" last="West">Kim West</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Herrmann, John E" sort="Herrmann, John E" uniqKey="Herrmann J" first="John E." last="Herrmann">John E. Herrmann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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